CBL enhances breast tumor formation by inhibiting tumor suppressive activity of TGF-β signaling
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چکیده
منابع مشابه
The ubiquitin E3 ligase ITCH enhances breast tumor progression by inhibiting the Hippo tumor suppressor pathway
The Hippo kinase pathway is emerging as a conserved signaling pathway that is essential for organ growth and tumorigenesis. Recently, we reported that the ubiquitin E3 ligase ITCH negatively regulates LATS1, thereby increasing YAP activity, which leads to increased cell proliferation and decreased apoptosis. Here, we investigated the role of ITCH in breast tumorigenesis. In particular, we show ...
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ژورنال
عنوان ژورنال: Oncogene
سال: 2012
ISSN: 0950-9232,1476-5594
DOI: 10.1038/onc.2012.18